Made in Japan Quality - COLLAGEN 13000


COLLAGEN 13000 contains 13000mg of highly scarce fish collagen. While fish collagen is known to be difficult for the body to digest and absorb, by conducting extensive research and product development we were able to produce an easily-absorbed collagen and an optimally balanced formula for achieving beautiful skin.

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Anatomy of the skin

The skin is the largest organ of the human body, composed of three layers of tissue: the epidermis (surface layer), the dermis (intermediate layer) and the hypodermis (deep layer).

The epidermis is divided into several layers. The outer layer of skin is the stratum corneum. Composed of a few layers of corneocytes (cells), it forms a semi-permeable protective natural barrier, which retains sufficient water to hydrate the skin in order to maintain its flexibility and deformability. The corneocytes are regularly replaced through desquamation and renewal from the lower epidermal layers.

The second layer of tissue is the dermis, composed of collagen fibers responsible for skin firmness, elastin proteins that maintain the skin’s suppleness, Hyaluronic acid which encourages the hydration of the skin and the ceramides (fats) working as a mortar between the skin cells, forming a protective layer that limits moisture loss and protects the skin against the environment. There are also fibroblast cells that synthesize the collagen molecules, working to maintain youthful skin.

To maintain the production of collagen by the fibroblast, the organism needs essential amino acids to build the collagen fibers.

What is collagen?

Collagen is found in animals, is the part of the skin tissue that helps to maintain firmness, elasticity, suppleness and ensures the constant renewal of skin cells.

It is the most abundant protein in animals. In humans, collagen constitutes around 35% of the total protein mass in the human body [1].

The collagen is composed of amino acids bound together to form a chain included in the collagen fibers mostly found in skin, bone, cartilage, tissue, and connective tissue such as tendons and ligaments, playing a pivotal role in their structure. The most common triplet amino acids in collagen are the proline, hydroxyproline and Glycine. You will find these three important amino acids in the COLLAGEN 13000 of HEXA BEAUTY.

Why does our skin lose its radiance?

Your skin is the first organ showing the marks of the passing time. Wrinkles, fine lines, sagging skin and dullness are all the visible signs of aging.

Naturally the skin will progressively slow down the production of important skin elements, including collagen.

Collagen synthesis decreases with aging [2], as shown in figure 2, the quantity of collagen begins to decline at about the age of 25 and continues to decrease thereafter. This observation is due to the age-associated fragmentation of the collagen fibrils leading to the disorganization of the dermal layer with alteration of the fibroblast [3].

The alteration of the skin structure and appearance occur as a natural consequence of aging influenced by internal factors (hormones, genetics, metabolism, etc.) but can be aggravated by external factors such as sun exposure, pollution, diet, stress, etc. These factors contribute to the acceleration of skin alteration leading to the appearance of aging marks on our skin [4]. The skin will lose its support, its elasticity, firmness and become drier, leading to the formation of wrinkles, and sagging skin, due to the loss of important proteins including elastin, hyaluronic acid, ceramide and collagen.

Development of HEXA BEAUTY’s Collagen 13000

Based on science and its expertise, HEXA BEAUTY has created its own product, to maintain your everyday natural collagen quotient, and to preserve your inner and outer health.

With a true effectiveness, HEXA BEAUTY offers you COLLAGEN 13000, a supplement drink rich in vitamins and essential amino acids. This complete formula helps your body to stimulate collagen production, essential protein to keep your body and skin youthful, limiting the appearance of time marks.

The COLLAGEN 13000 complementary drink offers four important characteristics that make this drink unique and effective every day.


A conscientious selection of collagen

Based on in vitro, clinical and preclinical research, HEXA BEAUTY has carefully selected its collagen ingredient.

Aware about the high molecular weight of the collagen molecule, we selected a hydrolysed collagen. Hydrolisis consist to cut the collagen molecule into smaller molecules, so that it can be absorbed easily by the intestinal barrier, before reaching the bloodstream and diffuses its actions all over the body [5].

In choosing our raw materials, we selected them, based on their origin, their quality and their efficiency.

To maximize the effectiveness of our product, and its accessibility for all, we selected a collagen of marine origin, derived from white fish from Canada.

According to Dr. Benjakul S., collagen from a marine source, is much more effective than from pork or other types of animals [6]. Ohara H.'s clinical study also showed that collagen peptides of marine origin were found in higher concentrations in human plasma than pork collagen, validating the fish collagen peptides to resist during digestion [7]. With strong and effective collagen peptides, HEXA BEAUTY has selected the best collagen for COLLAGEN 13000.

We are aware of the importance of the origin of our raw materials, for this reason our collagen is native to Canada, a country recognized for the quality of its marine origin raw materials.


An internal action for an external result

Now, we know that the collagen molecules in creams are not small enough to penetrate the skin’s epidermis. Collagen contained in creams is therefore considered only as a surface moisturizing component.

In the case of oral collagen, if the collagen molecules are not hydrolysed, the entire collagen molecule is too big to cross the intestinal barrier. Mentioned in Hexa point 1, to get all the benefits of collagen, it has to cross the barrier of the intestine, before reaching the blood system. Hence, HEXA BEAUTY chose hydrolysed collagen which means collagen reduced into smaller molecules, to easily penetrate the intestinal wall and circulate throughout the body via the bloodstream [5].

The diffusion of COLLAGEN 13000 in the bloodstream will allow the essential elements contained in it, to reach the deep layers of the skin and bring all its benefits.


The perfect quantity for a redoubtable efficiency

The essential point of COLLAGEN 13000 is mainly the amount of hydrolysed collagen in its formula. It contains two times more than most oral collagens on the market, offering a sure and visible efficiency on the skin.

According to clinical tests, to get the positive effect of the collagen drink you need to consume at least 6000 mg of hydrolysed collagen per day to trigger fibroblast activity in the dermis, which result in the natural production of collagen by the organism. This is where the full potential of COLLAGEN 13000 comes in. Our formula contains more than double the minimum amount to consume every day, in order to observe results on collagen production.

Supported by the toxicological study of Dr. Benjakul in 2018, the hydrolysed collagen from fish is extremely safe and you should feel comfortable taking COLLAGEN 13000 every day.

Thanks to COLLAGEN 13000, we assure you a sufficient and safe amount of collagen, to boost your organism and to keep you in good health, confident, and radiant in all circumstances!


The efficiency synergy between Collagen 13000 ingredients

The COLLAGEN 13000 product formula contains four key ingredients essential to maintaining healthy and youthful skin: Ceramides, Elastin Hyaluronic acid and of course collagen hydrolysed. These four ingredients are essential elements to keep skin firm, puffy, smooth, hydrated and elastic.

Another interesting ingredient known for its synergistic effectiveness with collagen is Vitamin C. A natural antioxidant, it reduces the attacks of free radicals created in the body from environmental stresses such as sun exposure, pollution, stress, etc. These free radicals are known to destroy the collagen fibers by fragmenting them, which weakens the structure of the skin and contributes to wrinkle formation.

In addition to this antioxidant activity, the in vitro study by Boyera et al. has shown that Vitamin C maintains the activity of two enzymes essential to collagen synthesis [8].

As mentioned above, collagen is a molecule formed of several chains coiled together, generally formed by three amino acids, proline, glycine, hydroxyproline. These three essential amino acids in collagen synthesis, are contained in the hydrolysis collagen selected by HEXA BEAUTY. The components of this hydrolysed compound will be used by fibroblasts, to naturally produce the collagen necessary for the structural maintenance of the skin.

All ingredients selected by HEXA BEAUTY, contribute to the collagen production, and are beneficial for the health and beauty of the skin.

Drinking COLLAGEN 13000 "right before going to bed" further enhances the benefits.

The effective consumption of collagen depends on both time of day and frequency of intake. Recent research shows that effectively using collagen requires daily and continuing consumption.

It is during the period from roughly 10pm to 2am that growth hormones are most actively secreted and skin metabolism is most active. This is the “golden time” when one’s skin is reborn. By drinking collagen before, and sleeping well during, this golden time, it is possible to effectively absorb collagen. By the next morning, you will feel the improved firmness and elasticity of your skin.